Email: DGAP
DRN code: DRN231
Chief Investigator: Prof David Dunger
What is DGAP?
DGAP is short for Type-1 Diabetes and Autoimmune disease: Genes, Biomarkers and Immune phenotypes. The genetic building blocks, genes/DNA, which are present in all of the cells of the body may determine whether an individual is at risk of developing type 1 diabetes. Recently, many genes have been identified that affect a person's risk of developing type 1 diabetes. A lot of these genes appear to be involved in the body's immune system. This system normally controls how our bodies respond to infection, but has also been shown to be involved in the development of diabetes.
This study is looking at the relationship between genes and diabetes by studying people with diabetes who have brothers/sisters without diabetes. Siblings are genetically similar to each other. By comparing them, this study is hoping to identify small genetic changes in the immune system that are associated with diabetes and can be detected by simple blood tests.
Who can take part?
Brothers and sisters aged between 5-40 yrs who do not have type 1 diabetes but who have a brother or sister who was diagnosed under the age of 18 yrs with type 1 diabetes.
Newly diagnosed patients with type I diabetes aged from 5 to under 18 years of age. Patients need to be recruited within three months from date of diagnosis.
Find out more
If you are interested in finding out more information about DGAP and how you may be able to help with the study you can telephone 01223 768616, email
d-gap@paed.cam.ac.uk or text DGAP to 81025