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Use of neuro imaging to investigate metabolic disorders related to diabetes
- Name
- Professor Stephanie Anne Amiel
- Address
- Diabetes Research Group
King’s College London School of Medicine
Bessemer Road, London - Postcode
- SE5 9PJ
- Telephone
- 0207 346 4161
- stephanie.amiel@kcl.ac.uk
- Host Institution
- King’s College London School of Medicine
We are diabetologists, physicists and psychiatrists using imaging to investigate metabolic disorders related to diabetes. 4 groups using neuroimaging to investigate the central control of metabolism and the impact of metabolic disorders on brain function are joined by investigators using imaging to examine metabolism in peripheral tissues and in insulin resistance and obesity.
Specific interests include disordered signalling between peripheral organs (liver, fat, gastro-intestinal tract and pancreas) in metabolic syndromes and the links between insulin resistance and abnormal brain and liver function. Research questions include:
- Investigation of linked abnormalities of metabolism, structure and function in brain, liver, muscle and fat in insulin resistance that may progress to obesity and Type 2 diabetes and the effect of established and new therapeutic agents on these, to explore the pathogenesis of insulin resistant Type 2 diabetes and insulin resistance syndromes and associations such as impaired cortical functioning, appetite control, liver and muscle function and metabolism
- Use of imaging as investigative tool/surrogate marker to identify new therapies with potential to modulate outcome of insulin resistance, obesity, Type 2 diabetes Methods include positron emission tomography, functional and structural magnetic resonance imaging, magnetic resonance spectroscopy, metabonomics and transcriptomics in human and animal models.
Membership
- Professor Stephanie A Amiel - Professor of Diabetic Medicine, King’s College London School of Medicine (convenor)
- Professor Andrew Blamire - Professor of MR Physics, University of Newcastle working with Prof Roy Taylor, University of Newcastle School of Medicine
- Professor Stephen Bloom - Professor of Medicine, Hammersmith Hospital and Imperial College London
- Dr Mark Evans - Honorary Consultant and Lecturer, Cambridge Univesity
- Dr Dan Flanagan - Honorary Senior Lecturer Peninsula Medical School
- Dr Kenneth Macleod - Consultant Physician and Reader in Medicine, Peninsula Medical School
- Dr Paul Marsden - Scientific Director/Non-Clinical Senior Lecturer in Radiological Sciences, King’s College London School of Medicine
- Dr Laurence Reed - Clinical Lecturer, Dept of Neuropsychology, Institute of Psychiatry, King’s College London
- Dr Jane Miranda Rosenthal - Clinical Senior Lecturer in Diabetes, University College London
- Professor Steven CR Williams - Professor of Imaging Sciences, Director and Head of Centre, Institute of Psychiatry, King’s College London